| Scout.com 2006 Midlands Hot 50 |
| Rank | Name | Pos | City (State) High School | Ht/Wt/40 | Commit |
| 1 | Gerald McCoy | DT | Oklahoma City (Okla.) Southeast | 6-4/275/5.0 | |
| 2 | Butch Lewis | OT | Denver (Colo.) Regis Jesuit | 6-5/280/5.2 | |
| 3 | Derek Burton | DE/DT | Muskogee (Okla.) | 6-2.245/5.0 | |
| 4 | Lamarr Houston | DE/DT | Colorado Springs (Colo.) Doherty | 6-2/258/4.9 | |
| 5 | Adrian Clayborn | DE | St. Louis (Mo.) Webster | 6-2/245/4.8 | |
| 6 | Dominique Franks | CB | Tulsa (Okla.) Union | 5-11.5/180/4.52 | |
| 7 | Seth Jensen | DT | Fort Morgan (Colo.) | 6-4/270/5.2 | Nebraska |
| 8 | D.J. Jones | OT | Omaha (Neb.) Central | 6-5/295/5.4 | Nebraska |
| 9 | Jermaine Gresham | TE | Ardmore (Okla.) | 6-6/226/4.7 | |
| 10 | Chase Nelson | DE | Tulsa (Okla.) Union | 6-3/240/5.0 | |
| 11 | Laron Moore | CB/FS | Midwest City (Okla.) | 5-9/181/4.7 | |
| 12 | Josh Freeman | QB | Grandview (Mo.) | 6-5/226/4.84 | Nebraska |
| 13 | Sam Bradford | QB | Putnam City (Okla.) North | 6-4/190/4.7 | Oklahoma |
| 14 | Greg Banks | DT | Denver (Colo.) Montbello | 6-5/260/5.2 | |
| 15 | Chad Roark | C | Ada (Okla.) | 6-2/285/5.3 | Florida State |
| 16 | Keith Williams | DT/OT | St. Louis (Mo.) McCluer North | 6-6/305/5.4 | |
| 17 | Chris Guarnero | C/G | Denver (Colo.) Mullen | 6-2.5/251/5.51 | |
| 18 | Aaron Cawlfield | S/LB | Columbia (Mo.) Hickman | 5-11/195/4.59 | Missouri |
| 19 | Jeremy Maclin | WR/CB | Kirkwood (Mo.) | 6-0/175/4.5 | |
| 20 | Jerry Brown | DE | St. Louis (Mo.) Vashon | 6-4.5/258/5.43 | |
| 21 | Ricky Henry | G | Omaha (Neb.) Burke | 6-3/290/5.5 | Nebraska |
| 22 | Paddy Mullen | TE/DE | St. Louis (Mo.) DeSmet | 6-5/262/4.9 | Notre Dame |
| 23 | Phil Strozier | CB | Kansas City (Mo.) Rockhurst | 6-0/185/4.5 | |
| 24 | Chase Beeler | G | Jenks (Okla.) | 6-3/275/5.4 | |
| 25 | Josh Johnson | RB | Ponca City (Okla.) | 5-10/190/4.55 | |
| 26 | Munir Prince | CB/RB | St. Louis (Mo.) DeSmet | 5-9.5/164/4.5 | Notre Dame |
| 27 | Tim Barnes | OL | Hughesville (Mo.) Northwest | 6-3.5/300/5.32 | Missouri |
| 28 | Willie Dyson | DE/LB | Kirkwood (Mo.) | 6-2/230/4.89 | |
| 29 | Scott Krebeihl | OT | Pratt (Kan.) | 6-6/272/5.5 | |
| 30 | Bradley Dedeaux | TE | Midwest City (Okla.) | 6-3/235/4.85 | |
| 31 | Jacob Seacrest | G | Stillwater (Okla.) | 6-4/280/5.4 | |
| 32 | Kenny Brown | WR | Putnam City (Okla.) North | 6-3/180/4.55 | |
| 33 | Derek Hall | DE/TE | Kansas City (Mo.) Rockhurst | 6-5/225/4.85 | |
| 34 | Sam Johnson | LB/RB | Eureka (Mo.) | 6-2/217/4.67 | |
| 35 | Myron McKinney | OL | Putnam City (Okla.) North | 6-3/300/5.4 | |
| 36 | George West | FS/WR | Oklahoma City (Okla.) Northeast | 5-8.5/165/4.65 | |
| 37 | Scott Crain | G/C | Bolivar (Mo.) | 6-2/288/5.31 | |
| 38 | Tyler Lawrence | QB | Shawnee Mission (Kan.) West | 6-2/200/4.7 | Kansas |
| 39 | Michael McNeil | TE | Kirkwood (Mo.) | 6-4/215/4.7 | |
| 40 | Quentin Davie | QB/LB | St. Louis (Mo.) Cardinal Ritter | 6-3.5/195/4.94 | Duke |
| 41 | Prince McKinney | CB/FS | Broken Arrow (Okla.) | 5-8.5/160/4.5 | |
| 42 | Kris Means | LB | Grand Junction (Colo.) | 6-0/211/4.69 | |
| 43 | Brandon Crow | LB | Comanche (Okla.) | 6-1.5/210/4.75 | Texas Tech |
| 44 | Dakota Lewis | LB | Sulphur (Okla.) | 6-1/190/4.6 | |
| 45 | Derrick Russell | WR | Omaha (Neb.) Central | 6-4/185/4.5 | |
| 46 | Chris Carney | CB/FS | Denver (Colo.) Mullen | 6-1/160/4.65 | |
| 47 | Jake Sharp | RB | Salina (Kan.) | 5-9.5/175/4.5 | Kansas |
| 48 | Aubrey Quarles | WR | Aurora (Colo.) Grandview | 6-0/185/4.54 | |
| 49 | Curt Hornback | DT/G | Oklahoma City (Okla.) Westmoore | 6-4/310/5.35 | |
| 50 | Niles Brinkley | CB/S | St. Louis (Mo.) Beaumont | 5-11/175/4.45 | |